MVIIC (P01484) Protein Card

General Information

Name	MVIIC
Alternative name(s)	M7c,SNX-230
Organism	Conus magus (Magus cone)
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Wild type
Protein precursor	MVIIC precursor (822)

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	VI/VII
Pharmacological family	omega conotoxin

Sequence

CKGKGAPCRKTMYDCCSGSCGRRGKC(nh2)

Modified residues

position	symbol	name
27	nh2	C-term amidation

Sequence evidence

nucleic acid level

Average Mass

2749.24

Monoisotopic Mass

2747.16

Isoelectric Point

12.35

Extinction Coefficient [280nm]

1490.00

Activity

Ki: Voltage-Gated Calcium Channels

Target	Organism	Ki		Competitor	Agonist	Ref
Ca_v2.1	R. norvegicus	0.60 (0.49-0.72) nM		¹²⁵I-MVIIC		Lewis,R.J. et al. (2000)
Ca_v2.2	R. norvegicus	7.0 (5.3-9.8) nM		¹²⁵I-GVIA		Lewis,R.J. et al. (2000)

References

Hillyard,D.R., Monje,V.D., Mintz,I.M., Bean,B.P., Nadasdi,L., Ramachandran,J., Miljanich,G., Azimi-Zoonooz,A., McIntosh,J.M., Cruz,L.J. et al. (1992) A new Conus peptide ligand for mammalian presynaptic Ca2+ channels Neuron 9:69-77

Farr-Jones,S., Miljanich,G.P., Nadasdi,L., Ramachandran,J. and Basus,V.J. (1995) Solution structure of omega-conotoxin MVIIC, a high affinity ligand of P-type calcium channels, using 1H NMR spectroscopy and complete relaxation matrix analysis J. Mol. Biol. 248:106-124

Lewis,R.J., Nielsen,K.J., Craik,D.J., Loughnan,M.L., Adams,D.A., Sharpe,I.A., Luchian,T., Adams,D.J., Bond,T., Thomas,L., Jones,A., Matheson,J.L., Drinkwater,R., Andrews,P.R. and Alewood,P.F. (2000) Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes J. Biol. Chem. 275:35335-35344

Nielsen,K.J., Adams,D., Thomas,L., Bond,T., Alewood,P.F., Craik,D.J. and Lewis,R.J. (1999) Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels J. Mol. Biol. 289:1405-1421

Internal links

Protein Precursor	MVIIC precursor (822)
Nucleic acids
Structure	OMEGA-CONOTOXIN MVIIC FROM CONUS MAGUS SOLUTION STRUCTURE OF OMEGA-CONOTOXIN MVIIC, A HIGH AFFINITY OF P-TYPE CALCIUM CHANNELS, USING 1H NMR SPECTROSCOPY AND COMPLETE RELAXATION MATRIX ANALYSIS

External links

Ncbi

1CNN_A, 1OMN_A

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Friday 3 February 2023