CcTx (P01510) Protein Card

General Information
Name CcTx
Alternative name(s) Excitotoxin CcTx
Organism Conus consors
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor CcTx precursor (6154)
Notes Cctx activates neuronal voltage‐gated sodium channels but its precise molecular target and mode of action remain to be elucidated (Le Gall et al. 1999). The serine residue at position 7 is glycosylated (Violette et al. 2012).

Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework IV
Pharmacological family

Modified residues
7gSrglycosylated serine
Sequence evidence protein level
Average Mass 3225.68
Monoisotopic Mass 3223.20
Isoelectric Point 8.09
Extinction Coefficient [280nm] 6990.00

Le Gall,F., Favreau,P., Benoit,E., Mattei,C., Bouet,F., Menou,J.L., Menez,A., Letourneux,Y. and Molgo,J. (1999) A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+-dependent mechanism Eur. J. Neurosci. 11:3134-3142
Violette,A., Biass,D., Dutertre,S., Koua,D., Piquemal,D., Pierrat,F. and Favreau,P. (2012) Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics 75:5215-5225

Internal links
Protein Precursor CcTx precursor (6154)
Nucleic acids
Structure NMR structure of the glycosylated conotoxin CcTx from Conus consors

External links
UniProtKB/Swiss-Prot P58928
Ncbi P58928, 4B1Q_P