PnIVB (P01559) Protein Card

General Information
Name PnIVB
Alternative name(s) Pn4b
Organism Conus pennaceus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor PnIVB precursor (771)
PnIVB precursor (618)
Notes Block tetrodotoxin resistant (TTX-R) Na channels (Fainzilber et al 1995). Complete block of voltage-gated Nav of Aplysia neurons at 80nM (Hasson et al. 1995). 5uM are required for complete blockade of Lymnea dissociated caudodorsal neurons (Fainzilber et al. 1995). No effect detect on mammalian systems (Fainzilber et al. 1995).

Conopeptide class conotoxin
Gene superfamily M superfamily
Cysteine framework IV
Pharmacological family mu conotoxin

Sequence evidence protein level
Average Mass 1864.18
Monoisotopic Mass 1862.61
Isoelectric Point 10.95
Extinction Coefficient [280nm] 12490.00

Fainzilber,M., Nakamura,T., Gaathon,A., Lodder,J.C., Kits,K.S., Burlingame,A.L. and Zlotkin,E. (1995) A new cysteine framework in sodium channel blocking conotoxins Biochemistry 34:8649-8656
Hasson,A., Fainzilber,M., Zlotkin,E. and Spira,M. (1995) Electrophysiological characterization of a novel conotoxin that blocks molluscan sodium channels Eur. J. Neurosci. 7:815-818

Internal links
Protein Precursor PnIVB precursor (771)
PnIVB precursor (618)
Nucleic acids

External links
UniProtKB/Swiss-Prot P58927
Ncbi P58927, 2116206B