GmVIA (P01598) Protein Card

General Information
Name GmVIA
Alternative name(s) Gm6a
Organism Conus gloriamaris
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor GmVIA precursor (3016)

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family delta conotoxin

Sequence
VKPCRKEGQLCDPIFQNCCRGWNCVLFCV
Sequence evidence protein level
Average Mass 3353.97
Monoisotopic Mass 3351.50
Isoelectric Point 11.06
Extinction Coefficient [280nm] 5500.00

Activity

IC50: Voltage-Gated Sodium Channels

TargetOrganismIC50Ref
Nav1.2R. norvegicus2.5uMSafo,P. et al. (2000)
Nav1.4R. norvegicus4.8uMSafo,P. et al. (2000)

References
Safo,P., Rosenbaum,T., Shcherbatko,A., Choi,D.Y., Han,E., Toledo-Aral,J.J., Olivera,B.M., Brehm,P. and Mandel,G. (2000) Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA J. Neurosci. 20:76-80
Shon,K.J., Hasson,A., Spira,M.E., Cruz,L.J., Gray,W.R. and Olivera,B.M. (1994) Delta-conotoxin GmVIA, a novel peptide from the venom of Conus gloriamaris Biochemistry 33:11420-11425
Hasson,A., Shon,K.J., Olivera,B.M. and Spira,M.E. (1995) Alterations of voltage-activated sodium current by a novel conotoxin from the venom of Conus gloriamaris J. Neurophysiol. 73:1295-1301

Internal links
Protein Precursor GmVIA precursor (3016)
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot Q9TWM7
Ncbi Q9TWM7, AAB32042

Tools