ViVA (P01672) Protein Card

General Information
Name ViVA
Alternative name(s) Vi1359,Vi5.3,Vi5a
Organism Conus virgo
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor ViVA precursor (2833)

Classification
Conopeptide class conotoxin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family

Sequence
ZCCITIPECCRI(nh2)
Modified residues
positionsymbolname
1ZPyroglutamic acid
13nh2C-term amidation
Sequence evidence protein level
Average Mass 1359.65
Monoisotopic Mass 1358.56
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Somatostatin receptors

TargetOrganism% inhibitionConcentrationAgonistRef
sst3H. sapiens10+/-1010 uM125I-[Tyr11]-somatostatin (0.05 nM)Petrel,C. et al. (2013)

References
Quinton,L., Le Caer,J.P., Vinh,J., Gilles,N. and Chamot-Rooke,J. (2006) Fourier transform mass spectrometry: a powerful tool for toxin analysis Toxicon 47:715-726
Mandal,A.K., Ramasamy,M.R., Sabareesh,V., Openshaw,M.E., Krishnan,K.S. and Balaram,P. (2007) Sequencing of T-superfamily conotoxins from Conus virgo: pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry. J. Am. Soc. Mass Spectrom. 18:1396-1404

Internal links
Protein Precursor ViVA precursor (2833)
Nucleic acids
Structure

External links
Ncbi P0C2B0

Tools