OIVB (P01688) Protein Card

General Information
Name OIVB
Alternative name(s) O4b
Organism Conus obscurus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Notes The superfamily assignment is not supported by any available data but the cDNA extraction method is based on the conservation of 5' and 3' UTR.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework IV
Pharmacological family alpha conotoxin

Sequence
CCGVONAACPOCVCNKTCG(nh2)
Modified residues
positionsymbolname
5O4-Hydroxyproline
11O4-Hydroxyproline
20nh2C-term amidation
Sequence evidence protein level
Average Mass 1865.16
Monoisotopic Mass 1863.66
Isoelectric Point 10.95
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus96uM1-10uM AchTeichert,R.W. et al. (2006)
α1β1γδM. musculus66nM1-10uM AchTeichert,R.W. et al. (2006)

References
Teichert,R.W., Lopez-Vera,E., Gulyas,J., Watkins,M., Rivier,J. and Olivera,B.M. (2006) Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor Biochemistry 45:1304-1312
Teichert,R.W., Rivier,J., Torres,J., Dykert,J., Miller,C. and Olivera,B.M. (2005) A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor J. Neurosci. 25:732-736

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0C1W8
Ncbi P0C1W8

Tools