PeIVA (P01689) Protein Card

General Information
Name PeIVA
Organism Conus pergrandis
Organism region Indo-Pacific
Protein Type Wild type
Notes The superfamily assignment is not supported by any available data but the cDNA extraction method is based on the conservation of 5' and 3' UTR.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework IV
Pharmacological family alpha conotoxin

Sequence
CCGVONAACHOCVCTGKC
Modified residues
positionsymbolname
5O4-Hydroxyproline
11O4-Hydroxyproline
Sequence evidence nucleic acid level
Average Mass 1792.07
Monoisotopic Mass 1790.61
Isoelectric Point 10.95
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus4.0uM+/-0.21-10uM AchTeichert,R.W. et al. (2006)
α1β1γδM. musculus<5nM1-10uM AchTeichert,R.W. et al. (2006)

References
Teichert,R.W., Lopez-Vera,E., Gulyas,J., Watkins,M., Rivier,J. and Olivera,B.M. (2006) Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor Biochemistry 45:1304-1312

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0C1W9
Ncbi P0C1W9

Tools