GIA (P00022) Protein Card

General Information
Name GIA
Alternative name(s) G1a
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence evidence protein level
Average Mass 1623.81
Monoisotopic Mass 1622.58
Isoelectric Point 9.72
Extinction Coefficient [280nm] 1490.00

Gray,W.R., Luque,A., Olivera,B.M., Barrett,J. and Cruz,L.J. (1981) Peptide toxins from Conus geographus venom J. Biol. Chem. 256:4734-4740
Nishiuchi,Y. and Sakakibara,S. (1982) Primary and secondary structure of conotoxin GI, a neurotoxic tridecapeptide from a marine snail FEBS Lett. 148:260-262
Gray,W.R., Luque,F.A., Galyean,R., Atherton,E., Sheppard,R.C., Stone,B.L., Reyes,A., Alford,J., McIntosh,M., Olivera,B.M., Cruz,L.J. and Rivier,J. (1984) Conotoxin GI: disulfide bridges, synthesis, and preparation of iodinated derivatives Biochemistry 23:2796-2802
Hann,R.M., Pagan,O.R. and Eterovic,V.A. (1994) The alpha-conotoxins GI and MI distinguish between the nicotinic acetylcholine receptor agonist sites while SI does not Biochemistry 33:14058-14063
Groebe,D.R., Dumm,J.M., Levitan,E.S. and Abramson,S.N. (1995) alpha-Conotoxins selectively inhibit one of the two acetylcholine binding sites of nicotinic receptors Mol. Pharmacol. 48:105-111
Groebe,D.R., Gray,W.R., and Abramson,S.N. (1997) Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors Biochemistry 36:6469-6474
Guddat,L.W., Martin,J.A., Shan,L., Edmundson,A.B. and Gray,W.R. (1996) Three-dimensional structure of the alpha-conotoxin GI at 1.2 A resolution Biochemistry 35:11329-11335
Kobayashi,Y., Ohkubo,T., Kyogoku,Y., Nishiuchi,Y., Sakakibara,S., Braun,W. and Go,N. (1989) Solution conformation of conotoxin GI determined by 1H nuclear magnetic resonance spectroscopy and distance geometry calculations Biochemistry 28:4853-4860
Pardi,A., Galdes,A., Florance,J. and Maniconte,D. (1989) Solution structures of alpha-conotoxin G1 determined by two-dimensional NMR spectroscopy Biochemistry 28:5494-5501
Maslennikov,I.V., Sobol,A.G., Gladky,K.V., Lugovskoy,A.A., Ostrovsky,A.G., Tsetlin,V.I., Ivanov,V.T. and Arseniev,A.S. (1998) Two distinct structures of alpha-conotoxin GI in aqueous solution Eur. J. Biochem. 254:238-247
Gehrmann,J., Alewood,P.F. and Craik,D.J. (1998) Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stability J. Mol. Biol. 278:401-415
Mok,K.H. and Han,K.H. (1999) NMR solution conformation of an antitoxic analogue of alpha-conotoxin GI: identification of a common nicotinic acetylcholine receptor alpha 1-subunit binding surface for small ligands and alpha-conotoxins Biochemistry 38:11895-11904

Internal links
Nucleic acids

External links
UniProtKB/Swiss-Prot P01519
Ncbi P01519