AnIA (P02501) Protein Card

General Information

Name	AnIA
Alternative name(s)	An1a
Organism	Conus anemone
Organism region	Indo-Pacific
Organism diet	vermivorous
Protein Type	Wild type

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

CCSHPACAANNQD(sTy)C(nh2)
Modified residues	position symbol name 14 sTy Sulfotyrosine 16 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	1673.77
Monoisotopic Mass	1672.47
Isoelectric Point	5.63
Extinction Coefficient [280nm]	1490.00

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		nhill	Agonist	Ref
α3β2	R. norvegicus	5.84nM		0.85	100uM Ach	Loughnan,M.L. et al. (2004)

References

Loughnan,M.L., Nicke,A., Jones,A., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2004) Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone J. Med. Chem. 47:1234-1241

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023