SIVA (P02524) Protein Card

General Information
Name SIVA
Alternative name(s) S4a,Spastic peptide
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor SIVA precursor (94)
SIVA precursor (3960)
Notes This peptide acts on the sodium channels and not the potassium channels as previously thought (Kelley et al. 2006).

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework IV
Pharmacological family

Sequence
ZKSLVP(gSr)VITTCCGYDOGTMCOOCRCTNSC(nh2)
Modified residues
positionsymbolname
1ZPyroglutamic acid
7gSrglycosylated serine
17O4-Hydroxyproline
22O4-Hydroxyproline
23O4-Hydroxyproline
31nh2C-term amidation
Sequence evidence protein level
Average Mass 3189.63
Monoisotopic Mass 3187.27
Isoelectric Point NA
Extinction Coefficient [280nm] NA

References
Santos,A.D., McIntosh,J.M., Hillyard,D.R., Cruz,L.J. and Olivera,B.M. (2004) The A-superfamily of conotoxins: structural and functional divergence J. Biol. Chem. 279:17596-17606
Wang,C.Z., Jiang,H., Ou,Z.L., Chen,J.S. and Chi,C.W. (2003) cDNA cloning of two A-superfamily conotoxins from Conus striatus Toxicon 42:613-619
Craig,A.G., Zafaralla,G., Cruz,L.J., Santos,A.D., Hillyard,D.R., Dykert,J., Rivier,J.E., Gray,W.R., Imperial,J., DelaCruz,R.G., Sporning,A., Terlau,H., West,P.J., Yoshikami,D. and Olivera,B.M. (1998) An O-glycosylated neuroexcitatory conus peptide Biochemistry 37:16019-16025
Kelley,W.P., Schulz,J.R., Jakubowski,J.A., Gilly,W.F. and Sweedler,J.V. (2006) Two toxins from Conus striatus that individually induce tetanic paralysis. Biochemistry 45:14212-14222

Internal links
Protein Precursor SIVA precursor (94)
SIVA precursor (3960)
Nucleic acids
Structure

External links
Ncbi P0C828, AAN86573

Tools