MIVA (P02527) Protein Card

General Information

Name	MIVA
Alternative name(s)	M4a
Organism	Conus magus (Magus cone)
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Wild type
Protein precursor	MIVA precursor (18)

Classification

Conopeptide class	conotoxin
Gene superfamily	A superfamily
Cysteine framework	IV
Pharmacological family	kappa conotoxin

Sequence

AO(Gla)LVV(gTr)A(gTr)TNCCGYNOMTICOOCMCTYS COOKRKO(nh2)
Modified residues	position symbol name 2 O 4-Hydroxyproline 3 Gla Gamma carboxylic glutamic acid 7 gTr glycosylated threonine 9 gTr glycosylated threonine 17 O 4-Hydroxyproline 22 O 4-Hydroxyproline 23 O 4-Hydroxyproline 31 O 4-Hydroxyproline 32 O 4-Hydroxyproline 36 O 4-Hydroxyproline 37 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	4771.29
Monoisotopic Mass	4767.92
Isoelectric Point	10.04
Extinction Coefficient [280nm]	2980.00

References

Santos,A.D., McIntosh,J.M., Hillyard,D.R., Cruz,L.J. and Olivera,B.M. (2004) The A-superfamily of conotoxins: structural and functional divergence J. Biol. Chem. 279:17596-17606

Internal links

Protein Precursor	MIVA precursor (18)
Nucleic acids
Structure

External links

Ncbi

P0C1X1

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Friday 1 December 2023