VcIA (P02539) Protein Card

General Information
Name VcIA
Alternative name(s) vc1a
Organism Conus victoriae
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor VcIA precursor (499)

Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Modified residues
14GlaGamma carboxylic glutamic acid
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1866.98
Monoisotopic Mass 1865.62
Isoelectric Point 5.52
Extinction Coefficient [280nm] 1490.00


IC50: Nicotinic acetylcholine receptors

α9α10R. norvegicus62.9nM+/-5.21.330uM AchNevin,S.T. et al. (2007)

Synthetic variants

Clark,R.J., Fischer,H., Nevin,S.T., Adams,D.J. and Craik,D.J. (2006) The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1 J. Biol. Chem. 281:23254-23263
Sandall,D.W., Satkunanathan,N., Keays,D.A., Polidano,M.A., Liping,X., Pham,V., Down,J.G., Khalil,Z., Livett,B.G. and Gayler,K.R. (2003) A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo Biochemistry 42:6904-6911
Jakubowski,J.A., Keays,D.A., Kelley,W.P., Sandall,D.W., Bingham,J.P., Livett,B.G., Gayler,K.R. and Sweedler,J.V. (2004) Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry J Mass Spectrom 39:548-557
Lang,P.M., Burgstahler,R., Haberberger,R.V., Sippel,W. and Grafe,P. (2005) A conus peptide blocks nicotinic receptors of unmyelinated axons in human nerves Neuroreport 16:479-483
Satkunanathan,N., Livett,B., Gayler,K., Sandall,D., Down,J. and Khalil,Z. (2005) Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones Brain Res. 1059:149-158
Nevin,S.T., Clark,R.J., Klimis,H., Christie,M.J., Craik,D.J. and Adams,D.J. (2007) Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Mol. Pharmacol. 72:1406-1410

Internal links
Protein Precursor VcIA precursor (499)
Nucleic acids

External links
Ncbi P69747