CVIA (P02548) Protein Card

General Information

Name	CVIA
Alternative name(s)	C6a,Ca063,catus-C1b
Organism	Conus catus
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Wild type
Protein precursor	CVIA precursor (1597) CVIA precursor (1195) CVIA precursor (1197) CVIA precursor (1200)

Classification

Conopeptide class	conotoxin
Gene superfamily	O1 superfamily
Cysteine framework	VI/VII
Pharmacological family	omega conotoxin

Sequence

CKSTGASCRRTSYDCCTGSCRSGRC(nh2)
Modified residues	position symbol name 26 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	2641.93
Monoisotopic Mass	2640.03
Isoelectric Point	12.52
Extinction Coefficient [280nm]	1490.00

Activity

Ki: Voltage-Gated Calcium Channels

Target	Organism	Ki		Competitor	Agonist	Ref
Cav2.1	R. norvegicus	850 (700-1020) nM		125I-MVIIC		Lewis,R.J. et al. (2000)
Cav2.2	R. norvegicus	0.56 (0.44-0.70) nM		125I-GVIA		Lewis,R.J. et al. (2000)

References

Lewis,R.J., Nielsen,K.J., Craik,D.J., Loughnan,M.L., Adams,D.A., Sharpe,I.A., Luchian,T., Adams,D.J., Bond,T., Thomas,L., Jones,A., Matheson,J.L., Drinkwater,R., Andrews,P.R. and Alewood,P.F. (2000) Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes J. Biol. Chem. 275:35335-35344

Himaya, S.W.A., Jin, A.H., Dutertre, S., Giacomotto, J., Mohialdeen, H., Vetter, I., Alewood, P.F. and Lewis, R.J. (2015) Comparative venomics reveals the complex prey capture strategy of the piscivorous cone snail Conus catus. Journal of proteome research 14:4372-4381

Internal links

Protein Precursor	CVIA precursor (1597) CVIA precursor (1195) CVIA precursor (1197) CVIA precursor (1200)
Nucleic acids
Structure

External links

Ncbi

P58917

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023