De13a (P02550) Protein Card

General Information

Name	De13a
Alternative name(s)	DeXIIIA
Organism	Conus delessertii
Organism region	Western Atlantic and Caribbean
Organism diet	vermivorous
Protein Type	Wild type
Protein precursor	De13a precursor (1500)
Notes	Position 5 is a serine in Aguilar et al 2005 but is an arginine in the ncbi card.

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	XIII
Pharmacological family

Sequence

DCOTSCOTTCANG(Btr)ECC(hLy)GYOCVN(hLy)ACSG CTH(nh2)
Modified residues	position symbol name 3 O 4-Hydroxyproline 7 O 4-Hydroxyproline 14 Btr Bromotryptophan 18 hLy 5-hydroxy-lysine 21 O 4-Hydroxyproline 25 hLy 5-hydroxy-lysine 33 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	3490.61
Monoisotopic Mass	3487.09
Isoelectric Point	5.52
Extinction Coefficient [280nm]	1490.00

References

Aguilar,M.B., López-Vera,E., Ortiz,E., Becerril,B., Possani,L.D., Olivera,B.M. and Heimer de la Cotera,E.P. (2005) A novel conotoxin from Conus delessertii with posttranslationally modified lysine residues Biochemistry 44:11130-11136

Internal links

Protein Precursor	De13a precursor (1500)
Nucleic acids
Structure

External links

Ncbi

P84698

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 26 September 2023