contryphan-M (P02570) Protein Card

General Information
Name contryphan-M
Alternative name(s) Mr014
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor contryphan-M precursor (1357)
contryphan-M precursor (5387)
contryphan-M precursor (6166)
contryphan-M precursor (6165)
Notes Contryphan-M is a disulfide poor conopeptide but was here annotated as part of the omega-conotoxin pharmacological family because (1) like the other peptide of this class contryphan-M is a blocker of calcium channels, and (2) the definition of the pharmacological families is only based on the type of activity and the family of targeted receptors.

Classification
Conopeptide class contryphan
Gene superfamily O2 superfamily
Pharmacological family omega conotoxin

Sequence
N(Gla)S(Gla)CPwHPWC(nh2)
Modified residues
positionsymbolname
2GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
7wD-tryptophan
12nh2C-term amidation
Sequence evidence protein level
Average Mass 1472.52
Monoisotopic Mass 1471.49
Isoelectric Point 2.20
Extinction Coefficient [280nm] 11000.00

References
Hansson,K., Ma,X., Eliasson,L., Czerwiec,E., Furie,B., Furie,B.C., Rorsman,P. and Stenflo,J. (2004) The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J. Biol. Chem. 279:32453-32463
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J. (2013) Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics 12:312-329

Internal links
Protein Precursor contryphan-M precursor (1357)
contryphan-M precursor (5387)
contryphan-M precursor (6166)
contryphan-M precursor (6165)
Nucleic acids
Structure

External links
Ncbi P62903

Tools