ImII (P02586) Protein Card

General Information
Name ImII
Organism Conus imperialis
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor ImII precursor (92)

Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Modified residues
13nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1509.76
Monoisotopic Mass 1508.61
Isoelectric Point 12.50
Extinction Coefficient [280nm] 5500.00


IC50: Nicotinic acetylcholine receptors

α1β1δεH. sapiens1.06uM1.0250nM AchEllison,M. et al. (2004)
9.5uM+/-3.8AchKasheverov,I.E. et al. (2006)
α2β2H. sapiens>10uM100uM AchEllison,M. et al. (2004)
α2β4H. sapiens>10uM100uM AchEllison,M. et al. (2004)
α3β2H. sapiens9.61uM1.1100uM AchEllison,M. et al. (2004)
α3β4H. sapiens>10uM100uM AchEllison,M. et al. (2004)
α4β2H. sapiens>10uM100uM AchEllison,M. et al. (2004)
α4β4H. sapiens>10uM100uM AchEllison,M. et al. (2004)
α7H. sapiens571nM1.11200uM AchEllison,M. et al. (2004)
1.5uMAchKasheverov,I.E. et al. (2009)
R. norvegicus441 nM1.195200 uM AchEllison,M.A. and McIntosh,J.M. and Olivera,B.M. (2003)

Synthetic variants

Kasheverov,I.E., Chiara,D.C., Zhmak,M.N., Maslennikov,I.V., Pashkov,V.S., Arseniev,A.S., Utkin,Y.N., Cohen,J.B. and Tsetlin,V.I. (2006) alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor FEBS J. 273:1373-1388
Ellison,M.A., McIntosh,J.M. and Olivera,B.M. (2003) alpha-Conotoxins ImI and ImII: similar alpha 7 nicotinic receptor antagonists act at different sites J. Biol. Chem. 278:757-764
Ellison,M., Gao,F., Wang,H.L., Sine,S.M. and Olivera,B.M. (2004) Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry 43:16019-16026

Internal links
Protein Precursor ImII precursor (92)
Nucleic acids

External links
Ncbi Q8I6R5, AAN78127