RVIIA (P02589) Protein Card

General Information

Name	RVIIA
Alternative name(s)	Light sleeper,R7a
Organism	Conus radiatus
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Wild type
Protein precursor	RVIIA precursor (1495)

Classification

Conopeptide class	conotoxin
Gene superfamily	O1 superfamily
Cysteine framework	VI/VII
Pharmacological family

Sequence

(Btr)FGH(Gla)(Gla)CTY(Btr)LGPC(Gla)VDDTCC SASC(Gla)SKFCGL(Btr)
Modified residues	position symbol name 1 Btr Bromotryptophan 5 Gla Gamma carboxylic glutamic acid 6 Gla Gamma carboxylic glutamic acid 10 Btr Bromotryptophan 15 Gla Gamma carboxylic glutamic acid 26 Gla Gamma carboxylic glutamic acid 33 Btr Bromotryptophan
Sequence evidence	protein level
Average Mass	4199.88
Monoisotopic Mass	4194.10
Isoelectric Point	1.74
Extinction Coefficient [280nm]	1490.00

References

Jimenez,E.C., Watkins,M. and Olivera,B.M. (2004) Multiple 6-bromotryptophan residues in a sleep-inducing peptide Biochemistry 43:12343-12348

Internal links

Protein Precursor	RVIIA precursor (1495)
Nucleic acids
Structure

External links

Ncbi

P0C1M8

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Sunday 28 May 2023