contulakin-G (P02618) Protein Card

General Information
Name contulakin-G
Alternative name(s) CGX-1160
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor contulakin-G precursor (1263)
contulakin-G precursor (1323)
Notes
  • Craig et al. (1999) showed that: (i) Synthetic glycosylated contulakin-G led to motor control-associated dysfunction in mice (intracranial injection); (ii) Contulakin-G was found to bind to human and rat neurotensin receptors, the non-glycosylated form is 10-fold less active.
  • Martin et al. (2021) demonstrated that: (i)Intrathecal injection of contulakin-G produces antinociception in both acute and chronic pain in mice; (ii)Contulakin-G antinociception is mediated through neurotensin receptor type 2 in mice; (iii) Inhibitory effect of contulakin-G on rat dorsal root ganglia is predominantly dependent on the inhibition of R-type (Cav2.3) and, to some extent, N-type (Cav2.2) currents; (iv) Contulakin-G antinociception is mediated through Cav2.3 channels in mice; (v) Contulakin-G inhibitory effect in the spinal cord is predominantly presynaptic. These findings together reveal a nonopioid pathway to produce analgesic compounds for intractable pain conditions.
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    Classification
    Conopeptide class contulakin
    Gene superfamily C superfamily
    Pharmacological family

    Sequence
    ZSEEGGSNA(gTr)KKPYIL
    Modified residues
    positionsymbolname
    1ZPyroglutamic acid
    10gTrglycosylated threonine
    Sequence evidence protein level
    Average Mass NA
    Monoisotopic Mass NA
    Isoelectric Point 5.63
    Extinction Coefficient [280nm] 1490.00

    References
    Craig,A.G., Norberg,T., Griffin,D., Hoeger,C., Akhtar,M., Schmidt,K., Low,W., Dykert,J., Richelson,E., Navarro,V., Mazella,J., Watkins,M., Hillyard,D., Imperial,J., Cruz,L.J. and Olivera,B.M. (1999) Contulakin-G, an O-glycosylated invertebrate neurotensin J. Biol. Chem. 274:13752-13759
    Martin,L., Ibrahim,M., Gomez,K., Yu,J., Cai,S., Chew,L.A., Bellampalli,S.S., Moutal,A., Largent-Milnes,T., Porreca,F., Khanna,R. and Patwardhan,A. (2021) Conotoxin contulakin-G engages a neurotensin receptor 2 /R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception. Pain

    Internal links
    Protein Precursor contulakin-G precursor (1263)
    contulakin-G precursor (1323)
    Nucleic acids
    Structure contulakin-G

    External links
    Ncbi AAD30031, Q9XYR5

    Tools