LtXVIA (P02623) Protein Card

General Information
Name LtXVIA
Alternative name(s) Lt16.1,Lt16a
Organism Conus litteratus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor LtXVIA precursor (1170)
Notes This sequence was directly derived from the precursor: some post-translational modifications may be missing. The final Arg residue is probably cleaved off but Zhou et al. (2015) studied the activity of this peptide (with the C-terminal Arg residue). Remarkably, this peptide inhibits both TTX-sensitive and TTX-resistant sodium currents in rat DRG.

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Cysteine framework XVI
Pharmacological family

Sequence
TGEDFLEECMGGCAFDFCCKR
Sequence evidence nucleic acid level
Average Mass 2357.63
Monoisotopic Mass 2355.87
Isoelectric Point 4.33
Extinction Coefficient [280nm] NA

References
Pi,C., Liu,J., Peng,C., Liu,Y., Jiang,X., Zhao,Y., Tang,S., Wang,L., Dong,M., Chen,S. and Xu,A. (2006) Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus Genomics 88:809-819
Zhou,M., Wang,L., Wu,Y., Liu,J., Sun,D., Zhu,X., Feng,Y., Qin,M., Chen,S. and Xu,A. (2015) Soluble expression and sodium channel activity of lt16a, a novel framework XVI conotoxin from the M-superfamily. Toxicon 98:5-11
Li,X., Chen,W., Zhangsun,D. and Luo,S. (2020) Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus. Mar Drugs 18

Internal links
Protein Precursor LtXVIA precursor (1170)
Nucleic acids
Structure

External links
Ncbi ABC74992

Tools