Vi6.1 (P02649) Protein Card

General Information
Name Vi6.1 (named by ConoServer)
Alternative name(s) Vi6a,conotoxin-1
Organism Conus virgo
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Vi6.1 precursor (1070)
Notes Espino et al.,2016 reported that Vi6.1 exhibited the inhibitory activity in 76 ± 10% of the DRG neurons. 2.0 mg/kg Vi6.1 injected into mice, resulted in the typical hyperactive phenotype; animals would climb the cage, jump and run around.

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family

Sequence
DCGGQGEGCYTQOCCOGLRCRGGGTGGGVCQL
Modified residues
positionsymbolname
13O4-Hydroxyproline
16O4-Hydroxyproline
Sequence evidence protein level
Average Mass 3116.40
Monoisotopic Mass 3114.19
Isoelectric Point 8.31
Extinction Coefficient [280nm] 1490.00

References
Kauferstein,S., Melaun,C. and Mebs,D. (2005) Direct cDNA cloning of novel conopeptide precursors of the O-superfamily Peptides 26:361-367
Espino,S.S., Dilanyan,T., Imperial,J.S., Aguilar,M.B., Teichert,R.W., Bandyopadhyay,P. and Olivera,B.M. (2016) Glycine-rich conotoxins from the Virgiconus clade. Toxicon 113:11-17

Internal links
Protein Precursor Vi6.1 precursor (1070)
Nucleic acids
Structure

External links
Ncbi CAH64854, CAH64855, Q5K0C7

Tools