Di19A (P02843) Protein Card

General Information

Name	Di19A
Alternative name(s)	Di16a,DiXIXA
Organism	Conus distans
Organism region	Indo-Pacific
Organism diet	vermivorous
Protein Type	Wild type
Protein precursor	Di19A precursor (2842)
Notes	Di19a causes hyperexcitable phenotype in mice greater than 3 weeks of age at lower doses, and lethargy at higher doses (Chen et al. 2008).

Classification

Conopeptide class	conotoxin
Gene superfamily	Divergent MSTLGMTLL-
Cysteine framework	XIX
Pharmacological family

Sequence

GCDOTDGCQTTVC(Gla)TDTGOCCCKPNFTCQISNSGTKS CSCSGQOSDCOV
Modified residues	position symbol name 4 O 4-Hydroxyproline 14 Gla Gamma carboxylic glutamic acid 19 O 4-Hydroxyproline 44 O 4-Hydroxyproline 48 O 4-Hydroxyproline
Sequence evidence	protein level
Average Mass	5065.37
Monoisotopic Mass	5061.78
Isoelectric Point	4.04
Extinction Coefficient [280nm]	NA

References

Chen,P., Garrett,J.E., Watkins,M. and Olivera,B.M. (2008) Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins. Toxicon 52:139-145

Internal links

Protein Precursor	Di19A precursor (2842)
Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 22 March 2023