Pn1.2 (P02917) Protein Card

General Information
Name Pn1.2
Organism Conus pennaceus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Pn1.2 precursor (2918)
Notes Carstens et al, 2016 reported that Pn1.2 inhibited HVA calcium channel currents in rat DRG neurons by 22%.

Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family

Sequence evidence nucleic acid level
Average Mass 1765.96
Monoisotopic Mass 1764.61
Isoelectric Point 6.60
Extinction Coefficient [280nm] 1490.00

Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O (2016) Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl 55:4692-4696

Internal links
Protein Precursor Pn1.2 precursor (2918)
Nucleic acids

External links