Lt5d (P03322) Protein Card

General Information
Name Lt5d
Alternative name(s) LtVd
Organism Conus litteratus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Lt5d precursor (1140)
Lt5d precursor (9819)
Notes Block tetrodotoxin sensitive (TTX-S) Na channels (Liu et al 2007).

Conopeptide class conotoxin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family mu conotoxin

Sequence evidence protein level
Average Mass 1275.53
Monoisotopic Mass 1274.49
Isoelectric Point 7.00
Extinction Coefficient [280nm] NA


IC50: Voltage-Gated Sodium Channels

Nav TTX-RR. norvegicus>150nMLiu,J. et al. (2007)
Nav TTX-SR. norvegicus156.16nMLiu,J. et al. (2007)

Percentage inhibition: Somatostatin receptors

TargetOrganism% inhibitionConcentrationAgonistRef
sst3H. sapiens0+/-1010 uM125I-[Tyr11]-somatostatin (0.05 nM)Petrel,C. et al. (2013)

Pi,C., Liu,J., Peng,C., Liu,Y., Jiang,X., Zhao,Y., Tang,S., Wang,L., Dong,M., Chen,S. and Xu,A. (2006) Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus Genomics 88:809-819
Liu,J., Wu,Q., Pi,C., Zhao,Y., Zhou,M., Wang,L., Chen,S. and Xu,A. (2007) Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels. Peptides 28:2313-2319
Li,X., Chen,W., Zhangsun,D. and Luo,S. (2020) Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus. Mar Drugs 18

Internal links
Protein Precursor Lt5d precursor (1140)
Lt5d precursor (9819)
Nucleic acids

External links