Lt5d (P03322) Protein Card

General Information
Name Lt5d
Alternative name(s) LtVd
Organism Conus litteratus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Lt5d precursor (1140)
Lt5d precursor (9819)
Notes Block tetrodotoxin sensitive (TTX-S) Na channels (Liu et al 2007).

Classification
Conopeptide class conotoxin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family mu conotoxin

Sequence
DCCPAKLLCCNP
Sequence evidence protein level
Average Mass 1275.53
Monoisotopic Mass 1274.49
Isoelectric Point 7.00
Extinction Coefficient [280nm] NA

Activity

IC50: Voltage-Gated Sodium Channels

TargetOrganismIC50Ref
Nav TTX-RR. norvegicus>150nMLiu,J. et al. (2007)
Nav TTX-SR. norvegicus156.16nMLiu,J. et al. (2007)

Percentage inhibition: Somatostatin receptors

TargetOrganism% inhibitionConcentrationAgonistRef
sst3H. sapiens0+/-1010 uM125I-[Tyr11]-somatostatin (0.05 nM)Petrel,C. et al. (2013)

References
Pi,C., Liu,J., Peng,C., Liu,Y., Jiang,X., Zhao,Y., Tang,S., Wang,L., Dong,M., Chen,S. and Xu,A. (2006) Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus Genomics 88:809-819
Liu,J., Wu,Q., Pi,C., Zhao,Y., Zhou,M., Wang,L., Chen,S. and Xu,A. (2007) Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels. Peptides 28:2313-2319
Li,X., Chen,W., Zhangsun,D. and Luo,S. (2020) Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus. Mar Drugs 18

Internal links
Protein Precursor Lt5d precursor (1140)
Lt5d precursor (9819)
Nucleic acids
Structure

External links

Tools