CVIF (P03340) Protein Card

General Information
Name CVIF
Alternative name(s) C6f
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGASCRRTSYDCCTGSCRLGRC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2665.06
Monoisotopic Mass 2663.12
Isoelectric Point 12.54
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50nhillRef
Cav1.2R. norvegicus>3uMBerecki,G. et al. (2010)
Cav1.3R. norvegicus>3uMBerecki,G. et al. (2010)
Cav2.2H. sapiens(Cav2.2 channels expressed in the SH-SY5Y cells)10 nM+/-3.1Hasan,M.M. et al. (2021)
R. norvegicus19.9nM+/-3.20.51Berecki,G. et al. (2010)
34.3 nM+/-2.10.42Berecki,G. et al. (2014)
Cav2.3R. norvegicus>3uMBerecki,G. et al. (2010)

Percentage inhibition: Voltage-Gated Calcium Channels

TargetOrganism% inhibitionConcentrationRef
Cav2.1R. norvegicus103uMBerecki,G. et al. (2010)

References
Berecki,G., Motin,L., Haythornthwaite,A., Vink,S., Bansal,P., Drinkwater,R., Wang,C.I., Moretta,M., Lewis,R.J., Alewood,P.F. and Adams,D.J. (2010) Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol Pharmacol 77:139-148
Berecki,G., Daly,N.L., Huang,Y.H., Vink,S., Craik,D.J., Alewood,P.F. and Adams,D.J. (2014) Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav 2.2 channels British journal of pharmacology 171:3313-3327
Hasan,M.M., Starobova,H., Mueller,A., Vetter,I. and Lewis,R.J. (2021) Subcutaneous ω-Conotoxins Alleviate Mechanical Pain in Rodent Models of Acute Peripheral Neuropathy. Mar Drugs 19

Internal links
Nucleic acids
Structure

External links

Tools