ImI [R7L] (P00034) Protein Card

General Information
Name ImI [R7L]
Organism synthetic construct
Protein Type Synthetic
Parent ImI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPLCAWRC(nh2)
Modified residues
positionsymbolname
13nh2C-term amidation
Average Mass 1308.52
Monoisotopic Mass 1307.47
Isoelectric Point 7.00
Extinction Coefficient [280nm] 5500.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α7H. sapiens33uM+/-180.39500uMRogers,J.P. et al. (2000)

References
McIntosh,J.M., Yoshikami,D., Mahe,E., Nielsen,D.B., Rivier,J.E., Gray,W.R. and Olivera,B.M. (1994) A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI J. Biol. Chem. 269:16733-16739
Rogers,J.P., Luginbuhl,P., Shen,G.S., McCabe,R.T., Stevens,R.C. and Wemmer,D.E. (1999) NMR solution structure of alpha-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors Biochemistry 38:3874-3882
Johnson,D.S., Martinez,J., Elgoyhen,A.B., Heinemann,S.F. and McIntosh,J.M. (1995) alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors Mol. Pharmacol. 48:194-199
Rogers,J.P., Luginbuhl,P., Pemberton,K., Harty,P., Wemmer,D.E. and Stevens,R.C. (2000) Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist J. Mol. Biol. 304:911-926

Internal links
Nucleic acids
Structure NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R7L

External links
Ncbi 1E75_A

Tools