Conopressin-T (P03556) Protein Card

General Information
Name Conopressin-T
Organism Conus tulipa (tulip cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor Conopressin-T precursor (7988)
Conopressin-T precursor (7989)
Conopressin-T precursor (7990)
Conopressin-T precursor (7987)
Notes

Selective V1a receptor antagonist [Dutertre 2008]

Dutt et al., 2019 reported that conopressin-T (5 μM) showed no effect on the zebrafish larvae.

Classification
Conopeptide class conopressin
Gene superfamily
Pharmacological family

Sequence
CYIQNCLRV(nh2)
Modified residues
positionsymbolname
10nh2C-term amidation
Sequence evidence protein level
Average Mass 1108.34
Monoisotopic Mass 1107.53
Isoelectric Point 11.65
Extinction Coefficient [280nm] 1490.00

References
Croker D., Dutertre S., Alewood P., and Lewis R. (2006) Discovery and pharmacology of conopressin-T, a novel vasopressin-like peptide from Conus tulipa. Acta Pharmacologica Sinica 27:351-351
Dutertre,S., Croker,D., Daly,N.L., Andersson,A., Muttenthaler,M., Lumsden,N.G., Craik,D.J., Alewood,P.F., Guillon,G. and Lewis,R.J. (2008) Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. J. Biol. Chem. 283:7100-7108
Dutt, M., Dutertre, S., Jin, A.H., Lavergne, V., Alewood, P.F. and Lewis, R.J. (2019) Venomics reveals venom complexity of the piscivorous cone snail, Conus tulipa Marine drugs 17:71
Dutt,M., Giacomotto,J., Ragnarsson,L., Andersson,Å., Brust,A., Dekan,Z., Alewood,P.F., and Lewis,R.J. (2019) The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa Scientific reports 9:17841

Internal links
Protein Precursor Conopressin-T precursor (7988)
Conopressin-T precursor (7989)
Conopressin-T precursor (7990)
Conopressin-T precursor (7987)
Nucleic acids
Structure Solution structure of conopressin-T

External links

Tools