KIIIA[Del1,S3/S4Aop,C9A] (P03581) Protein Card

General Information

Name	KIIIA[Del1,S3/S4Aop,C9A]
Alternative name(s)	K3A[Del1,S3/S4Aop,C9A],KIIIA[Del1,S3/S4Aop,C9A]
Organism	synthetic construct
Protein Type	Synthetic
Parent	KIIIA
Notes	Synthetic analog of KIIIA, C1 truncated, C9 to Ala substitution, S3 and S4 substituted with single unnatural residue 5-amino-3-oxo-pentanoic acid.

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	III
Pharmacological family	mu conotoxin

Sequence

CNC(Aop)KWARDHARCC(nh2)
Modified residues	position symbol name 4 Aop 5-amino-3-oxo-pentanoic acid 15 nh2 C-term amidation
Average Mass	1661.91
Monoisotopic Mass	1660.66
Isoelectric Point	11.73
Extinction Coefficient [280nm]	5500.00

References

Han,T.S., Zhang,M.M., Walewska,A., Gruszczynski,P., Robertson,C.R., Cheatham,T.E. 3rd, Yoshikami,D., Olivera,B.M., Bulaj,G. (2009) Structurally minimized μ-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics. ChemMedChem 4:406-414

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 27 March 2023