Cp20.3 precursor (P03590) Protein Card

General Information
Name Cp20.3 precursor
Organism Conus capitaneus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Precursor
Notes The Uniprot/Swiss-Prot card and the NCBI cards present a partial sequence published by Kauferstein et al. 2009, while Loughnan et al. 2009 presents the complete sequence, which is reported here.

Framework: This framework was assigned to be XII on discovery of VxXIIA , VxXIIB and VxXIIC 2006, which also had been used for conotoxins from the I superfamily (Brown et al. 2005). Loughnan et al. now propose framework designation XX (see reference).

Dimers: Mature D superfamily peptides form hetero-, homo- and pseudohomodimers (identical sequence, different posttranslational modifications). Entries for mature peptides in ConoServer are for monomers.

Conopeptide class conotoxin
Gene superfamily D superfamily
Pharmacological family

Sequence evidence nucleic acid level
Sequence region
[1-24]signal sequence
[25-45]pro region
[46-94]mature peptideCp20.3

Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J. (2009) Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry 48:3717-3729
Kauferstein,S., Kendel,Y., Nicke,A., Coronas,F.I., Possani,L.D., Favreau,P., Krizaj,I., Wunder,C., Kauert,G. and Mebs,D. (2009) New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors. Toxicon 54:295-301

Internal links
Nucleic acids Cp20.3 precursor, mRNA, partial cds.

External links
UniProtKB/Swiss-Prot C3VVN6
Ncbi ACP50601