Ms20.1 precursor (P03596) Protein Card

General Information
Name Ms20.1 precursor
Organism Conus mustelinus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Precursor
Notes alternative sequence has P in position 2

Framework: This framework was assigned to be XII on discovery of VxXIIA , VxXIIB and VxXIIC 2006, which also had been used for conotoxins from the I superfamily (Brown et al. 2005). Loughnan et al. now propose framework designation XX (see reference).

Dimers: Mature D superfamily peptides form hetero-, homo- and pseudohomodimers (identical sequence, different posttranslational modifications). Entries for mature peptides in ConoServer are for monomers.

Classification
Conopeptide class conotoxin
Gene superfamily D superfamily
Pharmacological family

Sequence
MLKLEMMLVVLLILPLFYFDAGG
QVVQRDWRSDGLARYLQR
GDR
DVRECNINTPGSSWGKCCLTRMCGPMCCARSGCTCVYH
WRRGHGCSCPG
Sequence evidence nucleic acid level
Sequence region
[1-23]signal sequence
[24-44]pro region
[45-93]mature peptideMs20.1

References
Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J. (2009) Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry 48:3717-3729

Internal links
Nucleic acids Ms20.1 precursor, mRNA
Structure

External links
UniProtKB/Swiss-Prot C4PWC3
Ncbi CAX51121, C4PWC3

Tools