PnIB precursor (P00036) Protein Card

General Information
Name PnIB precursor
Organism Conus pennaceus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Pharmacological family

Sequence
MGMRMMFTVFLLVVLATTVVS
FTSDRASDDGNAAASDLIAL
TIK
GCCSLPPCALSNPDYC
G
Sequence region
[1-21]signal sequence
[45-60]mature peptidePnIB

References
Conticello,S.G., Gilad,Y., Avidan,N., Ben-Asher,E., Levy,Z. and Fainzilber,M. (2001) Mechanisms for evolving hypervariability: the case of conopeptides Mol. Biol. Evol. 18:120-131
Fainzilber,M., Hasson,A., Oren,R., Burlingame,A.L., Gordon,D., Spira,M.E. and Zlotkin,E. (1994) New mollusc-specific alpha-conotoxins block Aplysia neuronal acetylcholine receptors Biochemistry 33:9523-9529
Wolfender,J.L., Chu,F., Ball,H., Wolfender,F., Fainzilber,M., Baldwin,M.A. and Burlingame,A.L. (1999) Identification of tyrosine sulfation in Conus pennaceus conotoxins alpha-PnIA and alpha-PnIB: further investigation of labile sulfo- and phosphopeptides by electrospray, matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry J Mass Spectrom 34:447-454
Luo,S., Nguyen,T.A., Cartier,G.E., Olivera,B.M., Yoshikami,D. and McIntosh,J.M. (1999) Single-residue alteration in alpha-conotoxin PnIA switches its nAChR subtype selectivity Biochemistry 38:14542-14548
Hu,S.H., Gehrmann,J., Alewood,P.F., Craik,D.J. and Martin,J.L. (1997) Crystal structure at 1.1 A resolution of alpha-conotoxin PnIB: comparison with alpha-conotoxins PnIA and GI Biochemistry 36:11323-11330

Internal links
Nucleic acids Conus pennaceus clone PnMGMR-01 conotoxin scaffold I precursor, mRNA, complete cds
Structure

External links
UniProtKB/Swiss-Prot P50985
Ncbi P50985, AAG60509

Tools