VxXXB precursor (P03631) Protein Card

General Information
Name VxXXB precursor
Alternative name(s) Vx97 precursor
Organism Conus vexillum
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Precursor
Notes The uniprot card presents a sequence difference with the original publication from Loughnan et al. 2009. The difference at position 91 is between a cysteine and an arginine. The sequence published in Loughnan et al. 2009 is here presented. It should be noted that the mutation of the cysteine into an arginine would change the framework.

Classification
Conopeptide class conotoxin
Gene superfamily D superfamily
Pharmacological family

Sequence
MPKLAVVLLVLLILPLSYFDAAGG
QAVQGDWRGNRLARDLQ
RGGR
DDESECIINTRDSPWGRCCRTRMCGSMCCPRNGCTCV
YHWRRGHGCSCPG
Sequence region
[1-24]signal sequence
[25-45]pro region
[46-96]mature peptideVxXXB

References
Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J. (2009) Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry 48:3717-3729
Prashanth,J.R., Dutertre,S., Jin,A.H., Lavergne,V., Hamilton,B., Cardoso,F.C., Griffin,J., Venter,D.J., Alewood,P.F. and Lewis,R.J. (2016) The role of defensive ecological interactions in the evolution of conotoxins. Mol. Ecol. 25:598-615

Internal links
Nucleic acids VxXXB precursor, mRNA
Structure

External links
UniProtKB/Swiss-Prot C4PWC2
Ncbi CAX51120

Tools