RgIA [Y10W] (P03633) Protein Card

General Information
Name RgIA [Y10W]
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCRWRCR
Average Mass 1593.83
Monoisotopic Mass 1592.63
Isoelectric Point 12.50
Extinction Coefficient [280nm] 5500.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α7R. norvegicus2.90uM1200uM AchEllison,M. et al. (2008)
α9α10R. norvegicus10.8nM1.450uM AchEllison,M. et al. (2008)

References
Ellison,M., Feng,Z.P., Park,A.J., Zhang,X., Olivera,B.M., McIntosh,J.M. and Norton,R.S. (2008) Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues. J. Mol. Biol. 377:1216-1227

Internal links
Nucleic acids
Structure RgIA [Y10W] solution structure

External links

Tools