Vc1.1[S4K] (P03660) Protein Card

General Information
Name Vc1.1[S4K]
Organism synthetic construct
Protein Type Synthetic
Parent Vc1.1

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCKDPRCNYDHPEIC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1848.07
Monoisotopic Mass 1846.70
Isoelectric Point 6.62
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus>3uM10 uM AchHalai,R. et al. (2009)
α3β4R. norvegicus>3uM10 uM AchHalai,R. et al. (2009)
α7R. norvegicus>3uM10 uM AchHalai,R. et al. (2009)
α9α10H. sapiens(a9 human a10 rat)84nM10uM AchHalai,R. et al. (2009)
R. norvegicus99nM10uM AchHalai,R. et al. (2009)

References
Halai,R., Clark,R.J., Nevin,S.T., Jensen,J.E., Adams,D.J. and Craik,D.J. (2009) Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor. J. Biol. Chem.
Sadeghi M, Carstens BB, Callaghan BP, Daniel JT, Tae HS, O Donnell T, Castro J, Brierley SM, Adams DJ, Craik DJ, Clark RJ (2018) Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1. ACS Chem. Biol. 13:1577-1587

Internal links
Nucleic acids
Structure

External links

Tools