Vc1.1[N9I] (P03681) Protein Card

General Information
Name Vc1.1[N9I]
Organism synthetic construct
Protein Type Synthetic
Parent Vc1.1

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCIYDHPEIC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1806.03
Monoisotopic Mass 1804.68
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus234nM10uM AchHalai,R. et al. (2009)
α3β4R. norvegicus>3uM10uM AchHalai,R. et al. (2009)
α7R. norvegicus963nM10uM AchHalai,R. et al. (2009)
α9α10H. sapiens(a9 human a10 rat)18nM10uM AchHalai,R. et al. (2009)
R. norvegicus9nM10uM AchHalai,R. et al. (2009)

References
Halai,R., Clark,R.J., Nevin,S.T., Jensen,J.E., Adams,D.J. and Craik,D.J. (2009) Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor. J. Biol. Chem.

Internal links
Nucleic acids
Structure

External links

Tools