SrIA/SrIB precursor (P03751) Protein Card

General Information

Name	SrIA/SrIB precursor
Organism	Conus spurius
Organism region	Western Atlantic and Caribbean
Organism diet	vermivorous
Protein Type	Precursor

Classification

Conopeptide class	conotoxin
Gene superfamily	A superfamily
Pharmacological family

Sequence

MGMRMMFTVFLLVVLATTVVS FTSDSAFDSRNVAANDKVSD MIALTAR RTCCSRPTCRMEYPELCG GRR
Sequence region	[1-21] signal sequence [22-48] pro region [49-66] mature peptide SrIB [49-66] mature peptide SrIA

References

López-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano Cassulini,R., Batista,C.V., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B. and Wanke,E. (2007) Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. 274:3972-3985

Internal links

Nucleic acids
Structure

External links

UniProtKB/Swiss-Prot	P85886
Ncbi	P85886

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 22 March 2023