Ac1.1a (P03833) Protein Card

General Information

Name	Ac1.1a
Organism	Conus achatinus
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Wild type
Protein precursor	Ac1.1a precursor (562) Ac1.1a precursor (570)

Classification

Conopeptide class	conotoxin
Gene superfamily	A superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

NGRCCHPACGKHFNC(nh2)
Modified residues	position symbol name 16 nh2 C-term amidation
Sequence evidence	nucleic acid level
Average Mass	1641.88
Monoisotopic Mass	1640.63
Isoelectric Point	11.81
Extinction Coefficient [280nm]	NA

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α1β1δ	M. musculus	3.2nM	+/-2.2	10uM Ach	Liu,L. et al. (2007)
α1β1γδ	M. musculus	35.9nM	+/-7.7	10uM Ach	Liu,L. et al. (2007)
α1β1;γ	M. musculus	>50uM		10uM Ach	Liu,L. et al. (2007)
α2β2	R. norvegicus	>5uM		100uM Ach	Liu,L. et al. (2007)
α3β4	R. norvegicus	>50uM		100uM Ach	Liu,L. et al. (2007)

References

Yuan,D.D., Han,Y.H., Wang,C.G. and Chi,C.W. (2007) From the identification of gene organization of alpha conotoxins to the cloning of novel toxins Toxicon 49:1135-1149

Liu,L., Chew,G., Hawrot,E., Chi,C. and Wang,C. (2007) Two potent alpha3/5 conotoxins from piscivorous Conus achatinus. Acta Biochim. Biophys. Sin. (Shanghai) 39:438-444

Internal links

Protein Precursor	Ac1.1a precursor (562) Ac1.1a precursor (570)
Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023