BuIA precursor (P00409) Protein Card

General Information

Name	BuIA precursor
Organism	Conus bullatus
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Precursor

Classification

Conopeptide class	conotoxin
Gene superfamily	A superfamily
Pharmacological family

Sequence

MFTVFLLVVLTTTVVS FPSDRASDGRNAAANDKASDVVTLV LK GCCSTPPCAVLYC GRRR
Sequence region	[1-16] signal sequence [44-56] mature peptide BuIA

References

Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H. (2006) NMR structure determination of alpha-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold Biochem. Biophys. Res. Commun. 349:1228-1234

Azam,L., Dowell,C., Watkins,M., Stitzel,J.A., Olivera,B.M. and McIntosh,J.M. (2005) Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors J. Biol. Chem. 280:80-87

Internal links

Nucleic acids	Alpha-conotoxin peptides Sequence 146 from patent US 6797808
Structure

External links

UniProtKB/Swiss-Prot	P69657
Ncbi	P69657

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 22 March 2023