Cal14.2c (P04158) Protein Card

General Information
Name Cal14.2c
Organism Conus californicus
Organism region Eastern Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor Cal14.2c precursor (4015)
Notes Zazueta-Favela et al., 2019 reported that cal14.2c increased intracellular IL-10 production in Treg (CD3+CD4+Foxp3+) cells and decreased intracellular IL-17 production after 72h of culture. Cal14.2c did not show any effect on T cell proliferation nor on Th1/Th2 balance.

Conopeptide class conotoxin
Gene superfamily L superfamily
Cysteine framework XIV
Pharmacological family

Sequence evidence nucleic acid level
Average Mass 1844.03
Monoisotopic Mass 1842.67
Isoelectric Point 7.88
Extinction Coefficient [280nm] 5500.00

Biggs,J.S., Watkins,M., Puillandre,N., Ownby,J.P., Lopez-Vera,E., Christensen,S., Moreno,K.J., Bernaldez,J., Licea-Navarro,A. and Olivera,B.M. (2010) Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol. Phylogenet. Evol. 56:1-12
Zazueta-Favela,D., Donis-Maturano,L., Licea-Navarro,A.F., Bernáldez-Sarabia,J., Dan,K.W.L., Cota-Arce,J.M., Escobedo,G. and De León-Nava,M.A. (2019) Marine peptides as immunomodulators: Californiconus californicus-derived synthetic conotoxins induce IL-10 production by regulatory T cells (CD4+Foxp3+) Immunopharmacol Immunotoxicol 41:463-468

Internal links
Protein Precursor Cal14.2c precursor (4015)
Nucleic acids

External links