Vc1.2 (P04200) Protein Card

General Information
Name Vc1.2
Organism Conus victoriae
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Vc1.2 precursor (4199)
Notes Like Vc1.1, this peptide inhibits calcium channels (Safavi-Hemami et al. 2011).

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSNPACMVNNPQIC
Sequence evidence nucleic acid level
Average Mass 1649.90
Monoisotopic Mass 1648.59
Isoelectric Point 7.00
Extinction Coefficient [280nm] -1.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus75nM+/-5 Ach (30–100 mM)Safavi-Hemami,H. et al. (2011)
α7R. norvegicus637nM+/-90 Ach (30–100 mM)Safavi-Hemami,H. et al. (2011)
α9α10R. norvegicus1uM Ach (30–100 mM)Safavi-Hemami,H. et al. (2011)

References
Safavi-Hemami,H., Siero,W.A., Kuang,Z., Williamson,N.A., Karas,J.A., Page,L.R., MacMillan,D., Callaghan,B., Kompella,S.N., Adams,D.J., Norton,R.S., and Purcell,A.W. (2011) Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? J. Biol. Chem. 286:22546-22557

Internal links
Protein Precursor Vc1.2 precursor (4199)
Nucleic acids
Structure Alpha-conotoxin Vc1.2

External links

Tools