MVIIA[K2A] (P04240) Protein Card

General Information

Name	MVIIA[K2A]
Organism	synthetic construct
Protein Type	Synthetic
Parent	MVIIA
Notes	IC50 of 1.2 nM on chick brain synaptic plasma membrane (competition with GVIA) (Kim 1995).

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	VI/VII
Pharmacological family	omega conotoxin

Sequence

CAGKGAKCSRLMYDCCTGSCRSGKC(nh2)
Modified residues	position symbol name 26 nh2 C-term amidation
Average Mass	2582.02
Monoisotopic Mass	2580.04
Isoelectric Point	11.95
Extinction Coefficient [280nm]	1490.00

References

Kim,J.I., Takahashi,M., Ohtake,A., Wakamiya,A. and Sato,K. (1995) Tyr13 is essential for the activity of omega-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers Biochem. Biophys. Res. Commun. 206:449-454

Schroeder,C.I., Nielsen,K.J., Adams,D.A., Loughnan,M., Thomas,L., Alewood,P.F., Lewis,R.J. and Craik,D.J. (2012) Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers 98:345-356

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Sunday 2 April 2023