FVIA (P04241) Protein Card

General Information
Name FVIA
Organism Conus fulmen
Organism region Indo-Pacific
Protein Type Wild type
Protein precursor FVIA precursor (4242)
Notes FVIA was reported to habe no significant effect against any other CaV subtype except for Cav2.2 (Lee et al.).

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGTGKSCSRIAYNCCTGSCRSGKC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2566.95
Monoisotopic Mass 2565.06
Isoelectric Point 11.95
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50Ref
Cav2.2H. sapiens11.5nM+/-1.4Lee,S. et al. (2010)

References
Lee,S., Kim,Y., Back,S.K., Choi,H.W., Lee,J.Y., Jung,H.H., Ryu,J.H., Suh,H.W., Na,H.S., Kim,H.J. and Kim,J.I. (2010) Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca2+ channels. Mol Pain 6:97

Internal links
Protein Precursor FVIA precursor (4242)
Nucleic acids
Structure Omega conotoxin-FVIA

External links

Tools