Vc1.1 [insC_GGAAGG] cyclic (P04244) Protein Card

General Information
Name Vc1.1 [insC_GGAAGG] cyclic (named by ConoServer)
Alternative name(s) cVc1.1
Organism synthetic construct
Protein Type Synthetic
Parent Vc1.1
Notes Castro et al., 2018 reported that Vc1.1 [ins_GGAAGG] cyclic caused greater inhibition than Vc1.1. of colonic nociceptors from both healthy (IC50 values, Vc1.1: 23.4 nM; cVc1.1: 12.2 nM) and CVH (IC50 values, Vc1.1: 10.2 nM; cVc1.1: 3.5 nM) mice.

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCNYDHPEICGGAAGG
Average Mass 2160.30
Monoisotopic Mass 2158.77
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

References
Clark,R.J., Jensen,J., Nevin,S.T., Callaghan,B.P. and Craik,D.J. (2010) The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angew. Chem. Int. Ed. Engl. 49:6545-6548
Castro J, Grundy L, Deiteren A, Harrington AM, O Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM (2018) Cyclic analogues of α‐conotoxin Vc1. 1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain British journal of pharmacology 175:2384-2398

Internal links
Nucleic acids
Structure Cyclic VC1.1 NMR structure
Racemic structure of cyclic Vc1.1 (cVc1.1-1)

External links

Tools