AuIB[insC_GGAAAGG] cyclic (P04250) Protein Card

General Information
Name AuIB[insC_GGAAAGG] cyclic (named by ConoServer)
Alternative name(s) cAuIB-7 (GGAAAGG)
Organism synthetic construct
Protein Type Synthetic
Parent AuIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
GCCSYPPCFATNPDCGGAAAGG
Average Mass 1997.17
Monoisotopic Mass 1995.70
Isoelectric Point 5.47
Extinction Coefficient [280nm] 1490.00

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α3β4R. norvegicus10+/-73uM50-100uM AchLovelace,E.S. et al. (2011)
(ribbon)2+/-210uM50-100uM AchLovelace,E.S. et al. (2011)

References
Lovelace,E.S., Gunasekera,S., Alvarmo,C., Clark,R.J., Nevin,S.T., Grishin,A.A., Adams,D.J., Craik,D.J., and Daly,N.L. (2011) Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization. Antioxid. Redox Signal. 14:87-95

Internal links
Nucleic acids
Structure

External links

Tools