PIIIA [R20A] (P04302) Protein Card

General Information

Name	PIIIA [R20A]
Organism	synthetic construct
Protein Type	Synthetic
Parent	PIIIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	III
Pharmacological family	mu conotoxin

Sequence

ZRLCCAFOKSCRSRQCKOHACC(nh2)
Modified residues	position symbol name 1 Z Pyroglutamic acid 8 O 4-Hydroxyproline 18 O 4-Hydroxyproline 23 nh2 C-term amidation
Average Mass	2533.97
Monoisotopic Mass	2532.06
Isoelectric Point	NA
Extinction Coefficient [280nm]	NA

References

McArthur,J.R., Singh,G., O Mara,M.L., McMaster,D., Ostroumov,V., Tieleman,D.P. and French,R.J (2011) Orientation of µ-Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding. Mol. Pharmacol. 80:219-227

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023