MrVIB [C9U,C25U] (P04304) Protein Card

General Information

Name	MrVIB [C9U,C25U]
Organism	synthetic construct
Protein Type	Synthetic
Parent	MrVIB

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	VI/VII
Pharmacological family	mu conotoxin

Sequence

ACSKKWEYUIVPILGFVYCCPGLIUGPFVCV
Modified residues	position symbol name 9 U Selenocystine (half) 25 U Selenocystine (half)
Average Mass	3368.74
Monoisotopic Mass	3491.47
Isoelectric Point	9.50
Extinction Coefficient [280nm]	8480.00

Activity

IC50: Voltage-Gated Sodium Channels

Target	Organism	IC50		Ref
Nav1.8	R. norvegicus	310nM		de Araujo,A.D. et al. (2011)
Nav TTX-R	R. norvegicus	26nM		de Araujo,A.D. et al. (2011)
Nav TTX-S	R. norvegicus	>1uM		de Araujo,A.D. et al. (2011)

References

de Araujo,A.D., Callaghan,B., Nevin,S.T., Daly,N.L., Craik,D.J., Moretta,M., Hopping,G., Christie,M.J., Adams,D.J. and Alewood,P.F. (2011) Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angew. Chem. Int. Ed. Engl. 50:6527-6529

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023