KIIIA [H12A] (P04309) Protein Card

General Information
Name KIIIA [H12A]
Organism synthetic construct
Protein Type Synthetic
Parent KIIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
CCNCSSKWCRDASRCC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1818.07
Monoisotopic Mass 1816.61
Isoelectric Point 11.73
Extinction Coefficient [280nm] 5500.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.2R. norvegicus10.8uMMcArthur,J.R. et al. (2011)
Nav1.4R. norvegicus110.5uMMcArthur,J.R. et al. (2011)
Nav1.7R. norvegicus19.3uMMcArthur,J.R. et al. (2011)

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationRef
Nav1.2R. norvegicus14+/-41uMZhang,M.M. et al. (2007)
Nav1.4R. norvegicus5+/-11uMZhang,M.M. et al. (2007)

References
Zhang,M.M., Green,B.R., Catlin,P., Fiedler,B., Azam,L., Chadwick,A., Terlau,H., McArthur,J.R., French,R.J., Gulyas,J., Rivier,J.E., Smith,B.J., Norton,R.S., Olivera,B.M., Yoshikami,D. and Bulaj,G. (2007) Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J. Biol. Chem. 282:30699-30706
McArthur,J.R., Singh,G., McMaster,D., Winkfein,R., Tieleman,D.P. and French,R.J. (2011) Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA. Mol. Pharmacol. 80:573-584

Internal links
Nucleic acids
Structure

External links

Tools