RDP-MII [R1ADMA] (P04318) Protein Card

General Information
Name RDP-MII [R1ADMA]
Organism synthetic construct
Protein Type Synthetic
Parent MII

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
(ADMA)DPGCCSNPVCHLEHSNLC(nh2)
Modified residues
positionsymbolname
1ADMAAsymmetric dimethylarginine
20nh2C-term amidation
Average Mass 2107.38
Monoisotopic Mass 2105.86
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
a7*α6β2*R. norvegicus(0.1nM epibatidine)14.7uM0.1nM epibatidinePucci,L. et al. (2011)
(0.1nM epibatidine)4.5nM0.1nM epibatidinePucci,L. et al. (2011)

References
Pucci,L., Grazioso,G., Dallanoce,C., Rizzi,L., De Micheli,C., Clementi,F., Bertrand,S., Bertrand,D., Longhi,R., De Amici,M. and Gotti,C. (2011) Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors. FASEB J. 25:3775-3789

Internal links
Nucleic acids
Structure

External links

Tools