CVID[K10R] (P04324) Protein Card

General Information

Name	CVID[K10R]
Organism	synthetic construct
Protein Type	Synthetic
Parent	CVID

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	VI/VII
Pharmacological family	omega conotoxin

Sequence

CKSKGAKCSRLMYDCCSGSCSGTVGRC(nh2)

Modified residues

position	symbol	name
28	nh2	C-term amidation

Average Mass

2784.23

Monoisotopic Mass

2782.13

Isoelectric Point

11.95

Extinction Coefficient [280nm]

1490.00

Activity

IC50: Voltage-Gated Calcium Channels

Target	Organism	IC50		Agonist	Ref
Ca_v2.2	R. norvegicus	57pM		GVIA	Mould,J. et al. (2004)

References

Mould,J., Yasuda,T., Schroeder,C.I., Beedle,A.M., Doering,C.J., Zamponi,G.W., Adams,D.J. and Lewis,R.J. (2004) The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J. Biol. Chem. 279:34705-34714

Schroeder,C.I., Nielsen,K.J., Adams,D.A., Loughnan,M., Thomas,L., Alewood,P.F., Lewis,R.J. and Craik,D.J. (2012) Effects of Lys2 to Ala2 substitutions on the structure and potency of Ï‰-conotoxins MVIIA and CVID. Biopolymers 98:345-356

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023