PVIIA [N24A] (P04370) Protein Card

General Information

Name	PVIIA [N24A]
Organism	synthetic construct
Protein Type	Synthetic
Parent	PVIIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	VI/VII
Pharmacological family	kappa conotoxin

Sequence

CRIONQKCFQHLDDCCSRKCNRFAKCV(nh2)
Modified residues	position symbol name 4 O 4-Hydroxyproline 28 nh2 C-term amidation
Average Mass	3225.76
Monoisotopic Mass	3223.43
Isoelectric Point	11.84
Extinction Coefficient [280nm]	NA

Activity

Percentage inhibition: Voltage-Gated Potassium Channels

Target	Organism	% inhibition		Concentration	Ref
Kv Shaker	D. melanogaster	1			Jacobsen,R.B. et al. (2000)

References

Jacobsen,R.B., Koch,E.D., Lange-Malecki,B., Stocker,M., Verhey,J., Van Wagoner,R.M., Vyazovkina,A., Olivera,B.M. and Terlau,H. (2000) Single amino acid substitutions in kappa-conotoxin PVIIA disrupt interaction with the shaker K+ channel J. Biol. Chem. 275:24639-24644

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023