MII [S4A] (P04381) Protein Card

General Information
Name MII [S4A]
Organism synthetic construct
Protein Type Synthetic
Parent MII

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCANPVCHLEHSNLC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1694.93
Monoisotopic Mass 1693.66
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus15.8nM100uM AchMcIntosh,J.M. et al. (2004)
18.1nM+/-1.81.770uM AchEverhart,D. et al. (2004)
α6/α3β2β3R. norvegicus733pM100uM AchMcIntosh,J.M. et al. (2004)

References
Everhart,D., Cartier,G.E., Malhotra,A., Gomes,A.V., McIntosh,J.M. and Luetje,C.W. (2004) Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors Biochemistry 43:2732-2737
McIntosh,J.M., Azam,L., Staheli,S., Dowell,C., Lindstrom,J.M., Kuryatov,A., Garrett,J.E., Marks,M.J. and Whiteaker,P. (2004) Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors. Mol. Pharmacol. 65:944-952

Internal links
Nucleic acids
Structure

External links

Tools